Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.1K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.3K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.3K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.8K
3.8K
Phylogeny01:23

Phylogeny

64.1K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
64.1K
Synteny and Evolution02:31

Synteny and Evolution

3.9K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.9K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

804
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
804

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A curated list of immune system associated genes related to cancer.

BMC genomic data·2026
Same author

Pharmacogenomic landscape of TNF inhibitors in the Middle Eastern Qatari population.

Frontiers in immunology·2025
Same author

Impact of Somatic Gene Mutations on Prognosis Prediction in De Novo AML: Unraveling Insights from a Systematic Review and Meta-Analysis.

Cancers·2025
Same author

Tissue microarray and liquid biopsy approaches identify EphB3, cMet, and miR-3168 as biomarkers of colorectal cancer.

Cell cycle (Georgetown, Tex.)·2025
Same author

Multi-omic analysis of longitudinal acute myeloid leukemia patient samples reveals potential prognostic markers linked to disease progression.

Frontiers in genetics·2024
Same author

Deletion in RMST lncRNA impairs hypothalamic neuronal development in a human stem cell-based model of Kallmann Syndrome.

Cell death discovery·2024
Same journal

Combining ultrastructure expansion microscopy with immunofluorescence and Oligopaint DNA FISH.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
Same journal

Bridging methodological gaps in avian cytogenetics: comprehensive and optimized protocols for chromosomal preparation in birds.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
Same journal

The role of satellite DNA-enriched heterochromatic variants in reproductive disorders: Insights from standardized cytogenetic analysis.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
Same journal

Cytogenomics of Myloplus tiete reveals conserved satellite DNAs since the Late Eocene in Serrasalmidae (Teleostei, Characiformes).

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
Same journal

Stable resynthesized Brassica napus lines show similar meiotic behaviour to established B. napus.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
Same journal

Characterization of neocentromeric marker chromosome derived from chromosome 11: a rare entity in four patients with acute leukemia.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology·2026
See all related articles

Related Experiment Video

Updated: Mar 9, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K

Capturing genomic relationships that matter.

Cameron S Osborne1, Borbála Mifsud2

  • 1Department of Medical and Molecular Genetics, King's College London, London, UK. cameron.osborne@kcl.ac.uk.

Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology
|January 13, 2017
PubMed
Summary
This summary is machine-generated.

The cell nucleus

Keywords:
Capture Hi-CHi-C pipelinesgenome organizationpromoter-enhancer interactions

More Related Videos

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.6K
A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

10.7K

Related Experiment Videos

Last Updated: Mar 9, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.9K
Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

16.6K
A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

10.7K

Area of Science:

  • Genomics
  • Molecular Biology
  • Cell Biology

Background:

  • The cell nucleus exhibits a strong interrelationship between genome form and function.
  • This connection spans multiple hierarchies, from chromosome positioning to gene expression patterns.
  • Long-range regulatory contacts drive spatial and temporal gene expression.

Purpose of the Study:

  • To discuss recent and prospective developments in methodologies and analytical tools.
  • To enable in-depth characterization of genomic contacts associated with nuclear functions.
  • To address experimental and bioinformatical bottlenecks in analyzing large-scale genomic data.

Main Methods:

  • Chromosome conformation capture (3C) methods and their integration with next-generation sequencing (NGS).
  • Development of new experimental and bioinformatical tools.
  • Advanced analytical approaches for characterizing genomic contacts.

Main Results:

  • Chromosome conformation capture has enabled scrutiny of long-range regulatory interactions.
  • NGS integration has expanded the scope of detected genomic contacts.
  • New methodologies are facilitating focused characterization of functional genomic contacts.

Conclusions:

  • Advances in 3C and NGS have revolutionized the study of genome organization and function.
  • New analytical tools are crucial for overcoming data analysis challenges.
  • Future developments will enable a more detailed understanding of nuclear genome organization and gene regulation.