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Arterial Stiffness in Aortic Stenosis: Relationship with Severity and Echocardiographic Procedures Response

Giuseppe Bruschi1, Alessandro Maloberti2,3, Paola Sormani2,3

  • 1Cardiology I, "A.De Gasperis" Department, Niguarda Ca Granda Hospital, Milan, Italy.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|January 13, 2017
PubMed

Insights

Arterial stiffness, measured by pulse wave velocity (PWV), correlates with aortic stenosis (AS) severity. Higher PWV predicts better outcomes after transcatheter aortic valve implantation (TAVI) for AS.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biomedical Engineering

Background:

  • Aortic stenosis (AS) may involve atherosclerotic-like processes in the valve.
  • The relationship between arterial stiffness and AS is not well understood.

Purpose of the Study:

  • To investigate the correlation between pulse wave velocity (PWV) and AS severity.
  • To assess PWV's relation to procedural response in surgical aortic valve replacement (AVR) and transcatheter aortic valve implantation (TAVI).

Main Methods:

  • Thirty patients with severe AS underwent either AVR (15) or TAVI (15).
  • Echocardiography and PWV were measured before (t0) and one week after (t1) the procedures.

Main Results:

  • Higher baseline PWV in the overall population correlated with increased transvalvular pressure gradients.
  • Greater procedural response was observed in patients with higher baseline PWV.
  • These findings were significant in the TAVI subgroup, but not in the AVR subgroup.

Conclusions:

  • PWV is linked to transvalvular gradients in patients undergoing AS procedures.
  • In TAVI patients, PWV can predict echocardiographic response.
  • Baseline PWV may aid in selecting TAVI candidates, pending further research.
Abstract

Keywords:
Aortic stenosisAortic valve replacementArterial stiffnessPulse wave velocityTranscatheter aortic valve implantation

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