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Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis

Changshui Liu1,2, Yamei Ding2, Mo Xian1

  • 1a CAS Key Lab of Biobased Materials , Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao , China.

Critical Reviews in Biotechnology
|January 13, 2017
PubMed
Summary

Sustainable production of 3-Hydroxypropionate (3HP) is achievable via fermentation. The malonyl-CoA pathway enables high yields of this versatile platform chemical, paving the way for biodegradable plastics and other valuable compounds.

Keywords:
3-Hydroxypropionate3HP toleranceacetyl-CoA carboxylasecarbon fluxenzyme engineeringmalonyl-CoA pathwaymalonyl-CoA reductasemetabolic engineeringsupply of energy and cofactor

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