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A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
Published on: February 27, 2019
Antioxidant Peptides from Terrestrial and Aquatic Plants Against Cancer
Enrique Marquez-Rios1, Carmen Lizette Del-Toro-Sanchez1
1Departamento de Investigacion y Posgrado en Alimentos, Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N, Col. Centro, 83000 Hermosillo, Sonora, Mexico.
Abstract:
Cancer is the leading cause of morbidity and mortality worldwide. Therefore, the search for new and less aggressive treatments is currently the focus of the anticancer research. An attractive alternative for this purpose is the use of bioactive peptides from plants. Plants live everywhere on Earth, both on land and in water, and they are a major source of diverse molecules with pharmacological potential as antioxidant peptides. Hence, this review focuses on the importance of the antioxidant activity of terrestrial and aquatic plant peptides against cancer throughout several mechanisms. The influence of the antioxidant activity of peptides by different factors such as molecular weight and amino acid composition as a crucial factor for anticancer activity is also revised. Furthermore, the relation of antioxidant activity with anticancer property as well as safety and legal aspects of protein hydrolysates and bioactive peptides for their use in cancer treatments is discussed.
Insights
Plant-derived bioactive peptides show promise as novel anticancer agents. Their antioxidant activity, influenced by factors like molecular weight, is key to their effectiveness against cancer, with safety and legal aspects also discussed.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Cancer remains a primary global health concern, driving research into novel, less aggressive treatments.
- Bioactive peptides derived from plants present a promising alternative therapeutic avenue.
- Plants are rich sources of diverse molecules with significant pharmacological potential, including antioxidant peptides.
Purpose of the Study:
- To review the importance of antioxidant activity in plant-derived peptides for cancer treatment.
- To explore the mechanisms by which these peptides exert anticancer effects.
- To discuss factors influencing peptide activity, safety, and legal considerations.
Main Methods:
- Literature review focusing on terrestrial and aquatic plant peptides.
- Analysis of mechanisms underlying antioxidant and anticancer activities.
- Examination of factors affecting peptide efficacy (e.g., molecular weight, amino acid composition).
Main Results:
- Plant peptides exhibit significant antioxidant activity, crucial for their anticancer properties.
- Antioxidant activity is modulated by peptide characteristics like molecular weight and amino acid profile.
- Various mechanisms contribute to the anticancer effects of these bioactive peptides.
Conclusions:
- Plant-derived bioactive peptides are a valuable resource for developing new anticancer strategies.
- Understanding peptide properties is essential for optimizing their therapeutic use.
- Further research into safety and regulatory aspects is needed for clinical application.
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