Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dependence01:17

Drug Dependence

1.8K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.8K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.5K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.5K
Restorative Care01:19

Restorative Care

2.4K
Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of Dyadic Care to Support Clinical, Administrative, and Service Wraparound Needs for the Opioid-Exposed Mother and Infant.

Journal of addiction medicine·2026
Same author

Alcohol Consumption During Pregnancy Among Women Aged 18-49 Years - United States, 2021-2024.

MMWR. Morbidity and mortality weekly report·2026
Same author

A Systematic Review of International Guidelines for Addressing Alcohol Use Disorder in Pregnancy.

Alcohol, clinical & experimental research·2026
Same author

Ethical conflict of advanced practice providers related to drug testing and reporting for maternity patients with opioid use disorder.

Journal of substance use and addiction treatment·2026
Same author

Methamphetamine Co-Use Among Pregnant Individuals Using Opioids in the United States, 2011-2023.

Obstetrics and gynecology·2026
Same author

Engaging and Motivating to Prevent Overdose Among Women via Effective Reentry: EMPOWER A Women-Centered Behavioral Health Reentry Model for Overdose Prevention.

Journal of correctional health care : the official journal of the National Commission on Correctional Health Care·2026

Related Experiment Video

Updated: Mar 8, 2026

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
05:04

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect

Published on: September 22, 2023

1.1K

Medically Assisted Withdrawal (Detoxification): Considering the Mother-Infant Dyad.

Hendrée E Jones1, Mishka Terplan, Marjorie Meyer

  • 1UNC Horizons and Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (HEJ); Departments of Psychiatry and Obstetrics and Gynecology, School of Medicine, Johns Hopkins University (HEJ); Behavioral Health System, Baltimore, MD (MT); Department of Obstetrics, Gynecology & Reproductive Sciences, University of Vermont, Burlington, VT (MM).

Journal of Addiction Medicine
|January 13, 2017
PubMed
Summary

Medically assisted withdrawal for opioid use disorder in pregnant women does not improve infant outcomes and increases maternal relapse risk. Long-term treatment is recommended over withdrawal for better maternal and newborn health.

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.2K
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.8K

Related Experiment Videos

Last Updated: Mar 8, 2026

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
05:04

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect

Published on: September 22, 2023

1.1K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

88.2K
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.8K

Area of Science:

  • Obstetrics and Gynecology
  • Addiction Medicine
  • Neonatal Health

Background:

  • Historical recommendations advised against medically assisted withdrawal for pregnant women due to concerns of maternal relapse and fetal demise.
  • Recent data challenge these recommendations, suggesting no association between medically assisted withdrawal and fetal demise.

Purpose of the Study:

  • To evaluate the efficacy and safety of medically assisted withdrawal compared to opioid agonist pharmacotherapy for pregnant women with opioid use disorder.
  • To assess the impact of medically assisted withdrawal on maternal relapse rates and neonatal abstinence syndrome (NAS).

Main Methods:

  • Review of recent case series data on pregnant women undergoing medically assisted withdrawal.
  • Comparison of outcomes between medically assisted withdrawal and opioid agonist pharmacotherapy.

Main Results:

  • Medically assisted withdrawal is not associated with fetal demise, but maternal relapse remains a significant concern (average 48% relapse rate).
  • Current data do not support a reduction in neonatal abstinence syndrome (NAS) with medically assisted withdrawal compared to opioid agonist pharmacotherapy.
  • Medically assisted withdrawal increases maternal relapse risk and does not improve newborn health outcomes.

Conclusions:

  • Medically assisted withdrawal is not equivalent to opioid agonist pharmacotherapy for the maternal-newborn dyad.
  • Treatment for opioid use disorder in pregnant women should prioritize long-term management for optimal maternal and infant outcomes.
  • Opioid agonist pharmacotherapy is recommended over medically assisted withdrawal for pregnant women.