Related Experiment Video
Updated: Mar 8, 2026
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Laurel T Tainsh1, Patrick A Coady, John H Sinard
1*Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT; †New England Retina Associates, Hamden, CT; and Departments of ‡Pathology; and §Medicine, Yale University School of Medicine, New Haven, CT.
Purpose:
To report a case of asymmetric deep stromal keratopathy in a patient with multiple myeloma.
Methods:
Case report and literature review.
Results:
An 85-year-old woman was found to have progressive visually significant left-sided deep stromal opacity in the setting of monoclonal gammopathy. Hematologic workup resulted in a diagnosis of IgG kappa multiple myeloma. Histopathology was significant for semicrystalline deposits in the posterior stroma. The patient's visual acuity improved to 20/50 7 months after penetrating keratoplasty. A similar deep stromal lesion appeared in the right eye 2 years after initial presentation.
Conclusions:
We present an unusual case of paraproteinemic keratopathy with a uniquely asymmetric presentation that resulted in a diagnosis of multiple myeloma.
