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Updated: Mar 8, 2026

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CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
Published on: June 25, 2017
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The Chimera Flap: A Quarter Century Odyssey
1From the Division of Plastic Surgery, Sacred Heart Hospital, Allentown, PA.
Annals of Plastic Surgery
|January 13, 2017
Summary
The chimera flap, a versatile compound flap, offers a valuable solution for complex reconstructive surgery. This innovative technique has proven effective and is now a standard in surgical repair.
Area of Science:
- Plastic Surgery
- Surgical Innovation
Background:
- Complex multidimensional defects pose significant challenges for reconstructive surgeons.
- Vascularized composite allotransplantation has been explored, but compound flaps offer a more accessible alternative.
Observation:
- The chimera flap, a subtype of compound flap, demonstrates exceptional versatility.
- It comprises multiple, independently vascularized components (e.g., bone, skin, muscle) joined only by a common vascular pedicle.
Findings:
- The chimera flap concept, introduced 25 years ago, has been successfully integrated into the surgical reconstructive repertoire.
- Its historical development and proven efficacy underscore its significance.
Implications:
- The chimera flap represents a significant advancement in reconstructive surgery, offering enhanced options for complex cases.
- Its adaptability and proven track record suggest continued relevance and application in surgical practice.
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