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Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

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Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training.

Vanessa D Sherk1, R Dana Carpenter, Erin D Giles

  • 11Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO; 2Department of Mechanical Engineering, University of Colorado Denver, Denver, CO; and 3Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO.

Medicine and Science in Sports and Exercise
|January 13, 2017
PubMed
Summary
This summary is machine-generated.

Nonsteroidal anti-inflammatory drug (NSAID) use before exercise did not hinder bone strength gains in rats. Higher intensity exercise may be needed to observe NSAID effects on bone adaptation.

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Area of Science:

  • Bone biology and biomechanics
  • Exercise physiology
  • Pharmacology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can impede bone formation after mechanical loading.
  • The impact of NSAIDs on exercise-induced bone adaptations is not fully understood.
  • This research investigates NSAID effects on bone structure and strength during exercise training.

Purpose of the Study:

  • To determine if NSAID administration before exercise attenuates exercise-induced gains in bone structure and strength.
  • To examine the interaction between NSAIDs and weight-bearing exercise on skeletal adaptations.

Main Methods:

  • Adult female Wistar rats were assigned to ibuprofen (IBU) or vehicle (VEH) and exercise (EX) or sedentary (SED) groups.
  • IBU or VEH was administered orally 1 hour before treadmill running (5 days/week for 12 weeks).
  • Micro-CT, mechanical testing, and finite element analysis quantified bone characteristics.

Main Results:

  • Exercise significantly increased tibia cortical area and bone strength estimates (P < 0.01).
  • Exercise enhanced failure load and reduced stress response to loading (P < 0.05).
  • Ibuprofen administration did not significantly alter any measured bone parameters.

Conclusions:

  • Pre-exercise ibuprofen administration did not prevent exercise-induced skeletal benefits in rats.
  • Future studies may require higher bone strain-inducing exercise protocols to detect NSAID effects.
  • NSAIDs may not inhibit exercise-related bone strengthening under these conditions.