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From K-space to Nucleotide: Insights Into the Radiogenomics of Brain Tumors
Nabil Elshafeey1, Islam Hassan, Pascal O Zinn
1*Department of Diagnostic Radiology, Neuroimaging Section, The University of Texas, MD Anderson Cancer Center †Department of Neurosurgery, Baylor College of Medicine ‡Department of Cancer System Imaging, The University of Texas, MD Anderson Cancer Center, Houston, TX.
Abstract:
Radiogenomics is a relatively new and exciting field within radiology that links different imaging features with diverse genomic events. Genomics advances provided by the Cancer Genome Atlas and the Human Genome Project have enabled us to harness and integrate this information with noninvasive imaging phenotypes to create a better 3-dimensional understanding of tumor behavior and biology. Beyond imaging-histopathology, imaging genomic linkages provide an important layer of complexity that can help in evaluating and stratifying patients into clinical trials, monitoring treatment response, and enhancing patient outcomes. This article reviews some of the important radiogenomic literatures in brain tumors.
