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Relation of serum and vitreous nesfatin-1 concentrations with diabetic retinopathy
Rongfeng Dai1, Guohua Deng2, Zhuo Sun2
1Department of Endocrinology, The Third People's Hospital of Changzhou, Changzhou, China.
Objective:
Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR).
Methods:
This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients.
Results:
Serum and vitreous nesfatin-1 concentrations were significantly lower in the diabetic patients than in the controls. NPDR patients had reduced vitreous nesfatin-1 concentrations compared with patients without DR. In addition, there were significantly lower serum and vitreous nesfatin-1 concentrations in PDR patients compared with the other three groups. Pearson correlation analysis showed that serum nesfatin-1 was negatively correlated with body mass index and fasting plasma glucose in diabetic patients.
Conclusion:
Serum and vitreous nesfatin-1 concentrations were negatively correlated with DR.
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