Riboflavin status in urban adolescents

We compared riboflavin status in 284 healthy adolescents attending an urban university hospital clinic with that of 43 adolescents with a variety of chronic medical conditions. Riboflavin status was determined by erythrocyte glutathione reductase activity and 24-hour dietary recall of riboflavin intake. The mean activity coefficient for the healthy adolescents was 1.08 (SD +/- 0.09) and 1.10 (SD +/- 1.01) in the chronically ill group. Significantly higher values were found in females of both groups (z = 4.90, p less than 0.0001). Seventeen (7%) of the healthy teenagers and seven (16%) of the chronically ill group had biochemical evidence of riboflavin deficiency (p less than 0.02). Although the mean daily intake of riboflavin for the total group exceeded the recommended daily allowance, there was significantly lower riboflavin intake in the subgroup of adolescents who had abnormal activity coefficients (z = 3.29, p less than 0.001). These data suggest that subclinical riboflavin deficiency may occur in adolescents and that deficiency may be related to dietary intake of riboflavin.