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The factors affecting survival in patients with bronchiectasis
Fatma Çiftçi1, Elif Şen1, Sevgi Behiye Saryal1
1Department of Chest Disease, Faculty of Medicine, Ankara University, Ankara, Turkey.
Turkish Journal of Medical Sciences
|January 13, 2017
Summary
Bronchiectasis has a high mortality rate. Factors like older age, comorbidities, low oxygen, pulmonary hypertension, and Pseudomonas aeruginosa infection increase the risk of death in patients with bronchiectasis.
Area of Science:
- Pulmonary Medicine
- Critical Care Medicine
Background:
- Non-cystic fibrosis bronchiectasis is a chronic respiratory condition with limited data on mortality predictors.
- Understanding mortality rates and influencing factors is crucial for patient management and prognosis.
Purpose of the Study:
- To determine the mortality rate in patients with non-cystic fibrosis bronchiectasis.
- To identify key factors that modify mortality in this patient population.
Main Methods:
- A cohort of 56 patients with bronchiectasis was followed for an average of 65.38 months.
- Data collected included demographics, comorbidities, smoking status, vaccination history, bronchiectasis characteristics, arterial blood gas analysis, respiratory function tests, and laboratory results.
Main Results:
- The overall mortality rate was 35.7% with a mean survival of 46.42 months.
- Significant mortality predictors included advanced age (HR: 2.031), comorbidities (HR: 1.984), reduced partial oxygen pressure (HR: 0.886), pulmonary hypertension (HR: 9.015), and Pseudomonas aeruginosa sputum infection (HR: 7.014).
Conclusions:
- Bronchiectasis is associated with substantial mortality.
- Key modifiable and non-modifiable factors influencing mortality include age, comorbidities, oxygenation status, pulmonary artery pressure, and specific bacterial infections.
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