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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

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Topical bisphosphonate augments fixation of bone-grafted hydroxyapatite coated implants, BMP-2 causes

Jorgen Baas¹, Marianne Vestermark¹, Thomas Jensen¹

¹Orthopaedic Research Laboratory, Aarhus University Hospital, 8000 Aarhus C, Denmark.

|January 14, 2017

Summary

This summary is machine-generated.

Zoledronate topical application to bone allografts improved implant fixation by reducing resorption without hindering new bone formation. Bone morphogenetic protein 2 (BMP2) accelerated resorption and weakened fixation.

Keywords:

Allograft Bisphosphonate Bone morphogenetic protein Implant fixation Joint replacement

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Regenerative Medicine

Background:

Bone allografts enhance implant fixation in joint replacements.
Bone morphogenetic proteins (BMPs) stimulate bone formation but can increase graft resorption.
Bisphosphonates inhibit bone resorption.

Purpose of the Study:

To evaluate if zoledronate counteracts BMP-induced accelerated graft resorption.
To determine if zoledronate interferes with BMP-induced bone formation.
To assess zoledronate's effect on allograft fixation in a canine model.

Main Methods:

Canine model of impaction bone grafting.
Cancellous allograft bone grafts treated with saline, zoledronate, BMP2, or BMP2+zoledronate.
Grafts impacted into HA-coated porous Ti implants.
Biomechanical fixation and allograft resorption assessed.

Main Results:

Zoledronate-treated allografts showed significantly better biomechanical fixation and less resorption.
BMP2 alone or with zoledronate accelerated resorption and decreased mechanical fixation.
BMP2 did not significantly increase new bone formation.

Conclusions:

Topical zoledronate is a valuable tool for augmenting bone grafts.
BMP2 use in bone grafting carries a high risk of resorption and mechanical weakening.
Optimal administration of zoledronate can enhance bone graft outcomes.