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Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research
Primavera A Spagnolo1, David Goldman1,2
1Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
Brain : a Journal of Neurology
|January 14, 2017
Summary
Neuromodulation techniques offer promising new ways to target brain circuits involved in addiction. Further research is needed to confirm the long-term safety and effectiveness of these innovative treatments for addictive disorders.
Area of Science:
- Neuroscience
- Psychiatry
- Public Health
Background:
- Addictive disorders represent a significant global health challenge with limited treatment efficacy.
- Addiction phenotypes are linked to neural circuit dysregulation, supported by preclinical and neuroimaging data.
Purpose of the Study:
- To review the current literature on neuromodulation interventions for addictive disorders.
- To highlight advancements, limitations, and future research directions in this field.
Main Methods:
- Review of existing literature on neuromodulation in addictive disorders.
- Inclusion of both invasive (deep brain stimulation) and non-invasive (repetitive transcranial magnetic stimulation, transcranial direct current stimulation) techniques.
Main Results:
- Neuromodulation interventions show potential for probing and remodeling impaired neural circuits in addiction.
- The current body of literature is limited, and long-term safety and efficacy require further investigation.
Conclusions:
- Neuromodulation presents a promising therapeutic avenue for addictive disorders.
- Continued research is essential to validate the safety and efficacy of these interventions for clinical application.
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