Elevated mean platelet volume is associated with poor outcome after mechanical thrombectomy

Area of Science:

• Neurology
• Hematology
• Cardiovascular Research

Background:

• Elevated mean platelet volume (MPV) indicates increased platelet activity.
• MPV may serve as a prognostic indicator in acute ischemic stroke patients undergoing medical therapy.

Purpose of the Study:

• To examine the association between MPV and functional outcomes.
• To assess outcomes 3 months after mechanical thrombectomy (MT) for acute anterior circulation stroke.

Main Methods:

• 153 patients undergoing MT for acute stroke were analyzed.
• MPV was measured on admission and patients were grouped by average MPV.
• Univariate, multivariate analyses, and ROC analysis were performed. MPV's predictive value was compared to the HIAT score.

Main Results:

• High MPV was linked to significantly lower functional independence (28.9% vs 57.1%).
• Elevated MPV (≥10.4 fL) independently predicted unfavorable outcomes (OR=3.93).
• Adding MPV to the HIAT score did not enhance its predictive power (AUC 0.70 vs 0.62, p=0.174).

Conclusions:

• Elevated MPV is an independent predictor of poor functional outcome.
• This finding applies to patients with acute anterior circulation stroke treated with MT.
• MPV assessment may aid in prognostication for stroke patients post-MT.