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Glucose Homeostasis: Regulation of Blood Glucose01:02

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TGR5, Not Only a Metabolic Regulator.

Cong Guo1, Wei-Dong Chen2, Yan-Dong Wang1

  • 1State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology Beijing, China.

Frontiers in Physiology
|January 14, 2017
PubMed
Summary
This summary is machine-generated.

The G-protein-coupled bile acid receptor (TGR5) regulates metabolism and has emerging roles in inflammation and cancer. TGR5 is a promising drug target for various diseases.

Keywords:
GPCRGpbar1TGR5bile acidsreceptor

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a key player in the G-protein-coupled receptor (GPCR) superfamily.
  • TGR5 exhibits high mRNA expression in various tissues, including the small intestine, stomach, liver, lung, placenta, and spleen.

Approach:

  • This review summarizes the fundamental information regarding TGR5.
  • It explores TGR5's role as a receptor for bile acids and synthetic agonists like 6-EMCA and benzofuranyloxynicotinamide derivatives.
  • The review examines TGR5's regulation of signaling pathways including NF-κB, AKT, and ERK.

Key Points:

  • TGR5 functions as a metabolic regulator, influencing energy, bile acid, and glucose homeostasis.
  • Emerging research reveals TGR5's involvement in inflammatory responses, cancer, and liver regeneration.
  • TGR5's diverse functions highlight its potential as a therapeutic target.

Conclusions:

  • TGR5 is a multifaceted receptor with significant implications beyond metabolic regulation.
  • Its expanded roles in inflammation and cancer present new avenues for therapeutic intervention.
  • Further research into TGR5's functions could lead to novel drug development for various diseases.