Related Experiment Video
Updated: Mar 8, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Social Phobia Is Associated with Delayed Onset of Chickenpox, Measles, and Mumps Infections
Vladeta Ajdacic-Gross1, Aleksandra Aleksandrowicz2, Stephanie Rodgers2
1Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zürich, Switzerland.
Insights
Delayed common viral childhood diseases, such as measles and chickenpox, were associated with social phobia. This finding suggests a link between the timing of infections and the development of early anxiety disorders.
Area of Science:
- Childhood developmental psychology
- Epidemiology of mental health disorders
- Infectious disease research
Background:
- Growing evidence links childhood infectious diseases to neurodevelopmental and mental health disorders.
- The temporal relationship between common childhood illnesses and anxiety disorders requires further investigation.
Purpose of the Study:
- To investigate the timing of common childhood diseases in relation to early-onset anxiety disorders.
- To explore potential associations between specific viral infections and social phobia.
Main Methods:
- Analysis of data from the Swiss Population Cohort Study (PsyCoLaus, N=3720).
- Regression analysis correlating the age of onset of viral childhood diseases (chickenpox, measles, mumps) with specific anxiety disorders (social phobia, separation anxiety disorder, specific phobias).
- Statistical adjustments for other anxiety disorders and sex.
Main Results:
- A delayed onset of viral childhood diseases was consistently observed in individuals with social phobia.
- This association was noted in both male and female participants.
- No evidence suggested that phobia symptoms preceded the onset of the studied infections.
Conclusions:
- Social phobia emerged as the sole early-onset anxiety disorder associated with a delayed onset of common viral childhood diseases.
- The findings highlight a potential etiological link between the timing of viral infections and the development of social phobia.
Objective:
Evidence showing that infectious diseases in childhood play an important role in the etiopathogenesis of neurodevelopmental and other mental disorders is growing. The aim of this study was to explore the timing of common childhood diseases in early-onset anxiety disorders.
Materials And Methods:
We analyzed data from PsyCoLaus, a large Swiss Population Cohort Study (N = 3720). In this study, we regressed overanxious disorder, separation anxiety disorder, social phobia, and specific phobias on the age of onset of several childhood diseases, always adjusting for the other anxiety disorders listed above and for sex.
Results:
The timing of viral childhood diseases (chickenpox, measles, and mumps) was consistently delayed in social phobia, notably both in men and women. We found no evidence for a reversed sequence of onset of phobia symptoms before that of the infections included.
Conclusion:
Social phobia was the only early anxiety disorder to show an association with a delayed onset of common viral childhood diseases.
More Related Videos
Related Concept Videos
Social Anxiety Disorder
Autism Spectrum Disorder
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Personality Disorders: Paranoid and Schizoid
Paranoid Personality Disorder
Paranoid personality disorder is...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Preparedness and Phobias
Psychological and Sociocultural Causes of Schizophrenia

