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Related Experiment Videos

Bioabsorption of polylactides with different molecular properties.

T Nakamura1, S Hitomi, S Watanabe

  • 1Department of Experimental Surgery, Kyoto University, Japan.

Journal of Biomedical Materials Research
|October 1, 1989
PubMed
Summary

Polylactide absorption rates depend on composition and purity. Higher lactic acid content slows absorption, while residual monomers accelerate degradation and affect molecular weight.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Degradation

Background:

  • Polylactides are widely used biodegradable polymers in medical applications.
  • Understanding their bioabsorption rate is crucial for predicting device performance and longevity.
  • Factors influencing polylactide degradation require detailed investigation.

Purpose of the Study:

  • To investigate the impact of chemical composition, residual monomer content, and molecular orientation on polylactide bioabsorption rates.
  • To correlate material properties with degradation kinetics and structural changes in vivo.
  • To compare the degradation behavior of purified polylactides versus those with residual monomers.

Main Methods:

  • In vivo implantation tests in rabbits using polylactide samples of varying compositions and monomer content.

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  • Analysis of bioabsorption rates, molecular weight changes, and structural alterations (microporosity) over time.
  • Scanning electron microscopy (SEM) to visualize surface and internal structural changes.

    • Main Results:

    • Copolymer samples with higher lactic acid content exhibited slower bioabsorption.
    • Samples with higher unreacted monomer content degraded faster, showing significant molecular weight reduction.
    • Purified poly-L-lactide demonstrated slow degradation with minimal weight change but a 50% molecular weight reduction over 6 months.
    • Monomer-containing samples developed microporosity rapidly, unlike purified poly-L-lactide.

    Conclusions:

    • Residual monomers significantly accelerate polylactide bioabsorption and molecular degradation.
    • Material composition, particularly lactic acid content, influences degradation kinetics.
    • Purified polylactides exhibit markedly slower and more controlled degradation, essential for predictable in vivo performance.