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ADAMTS-4 in central nervous system pathologies

Sighild Lemarchant1, Sara Wojciechowski1, Denis Vivien2

  • 1A. I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, P.O. BOX 1627, 70211, Kuopio, Finland.

Journal of Neuroscience Research
|January 14, 2017
PubMed

Insights

ADAMTS-4, a key enzyme in cartilage breakdown, also plays a significant role in the central nervous system (CNS). This review explores its impact on neuroplasticity, neuroinflammation, and neurodegeneration in various CNS diseases.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs type 4) is known for degrading chondroitin sulfate proteoglycans, contributing to cartilage breakdown in arthritis.
  • Its role in the central nervous system (CNS) under physiological and pathological conditions is less understood.

Purpose of the Study:

  • To review the expression of ADAMTS-4 in the CNS during health and disease.
  • To elucidate the role of ADAMTS-4 in neuroplasticity, neuroinflammation, and neurodegeneration in CNS disorders.
  • To discuss potential therapeutic strategies targeting ADAMTS-4 in CNS diseases.

Main Methods:

  • Literature review focusing on studies investigating ADAMTS-4 expression and function in the CNS.
  • Analysis of ADAMTS-4's involvement in conditions such as spinal cord injury, ischemic stroke, ALS, and Alzheimer's disease.

Main Results:

  • ADAMTS-4 expression is modified in various CNS physiological and pathological states, including chronic diseases and injuries.
  • ADAMTS-4 contributes to mechanisms underlying neuroplasticity, neuroinflammation, and neurodegeneration in the CNS.
  • The enzyme influences the pathophysiology of diverse CNS diseases.

Conclusions:

  • ADAMTS-4 is a multifaceted metalloproteinase with significant influence on CNS disease processes.
  • Understanding ADAMTS-4's role opens avenues for novel therapeutic interventions in neurological disorders.
Keywords:
ADAMTS-4acute CNS injuriesamyotrophic lateral sclerosisneurodegenerationneuroinflammationneuroplasticity

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