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Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
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In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost-Effective, Metal-Assisted
Nancy Wareing1, Kyle Szymanski1, Giridhar R Akkaraju1
1Department of Biology, Texas Christian University, Fort Worth, TX, 76129, USA.
Small (Weinheim an Der Bergstrasse, Germany)
|January 14, 2017
Abstract:
The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.

