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Platelet-Rich Plasma Application for Acute Tympanic Membrane Perforations
Selmin Karataylı Özgürsoy1, M Emin Tunçkaşık, Fatma Tunçkaşık
1Department of Otolaryngology, Ufuk University School of Medicine, Ankara, Turkey. selminkrt@hotmail.com.
The Journal of International Advanced Otology
|January 14, 2017
Summary
Platelet-rich plasma (PRP) significantly speeds the healing of acute tympanic membrane perforations (TMPs) in rabbits. Long-term outcomes were similar between PRP-treated and control groups.
Area of Science:
- Otolaryngology
- Regenerative Medicine
- Wound Healing
Background:
- Acute tympanic membrane perforations (TMPs) can impair hearing and predispose to infection.
- Current treatments for TMPs vary, and faster healing methods are desirable.
- Platelet-rich plasma (PRP) is a concentration of growth factors that may promote tissue repair.
Purpose of the Study:
- To evaluate the efficacy of platelet-rich plasma (PRP) in accelerating the closure of acute tympanic membrane perforations (TMPs).
Main Methods:
- Acute TMPs were surgically created in rabbits, with PRP applied to one ear and the other serving as a control.
- Perforation closure was monitored daily.
- Histopathological analysis of seven parameters was performed post-sacrifice.
Main Results:
- PRP significantly reduced the time to closure for TMPs (12 days vs. 17.7 days, p=0.0145).
- No significant differences were observed in long-term histopathological parameters between PRP and control groups.
- Sclerosis and fibroblastic reactions were absent in both groups.
Conclusions:
- PRP effectively accelerates the healing of acute TMPs in a rabbit model.
- While PRP speeds closure, long-term microscopic and macroscopic outcomes are comparable to untreated TMPs.
- These findings support further clinical investigation of PRP for acute TMP treatment.
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