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Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans
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Kinetics of aggregation with choice.

E Ben-Naim1, P L Krapivsky2

  • 1Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

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|January 14, 2017
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Summary
This summary is machine-generated.

Aggregation with choice modifies cluster size distribution. While standard scaling persists, small clusters show anomalous scaling, and small/large clusters are overpopulated, unlike ordinary aggregation.

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Area of Science:

  • Statistical Physics
  • Complex Systems Modeling

Background:

  • Ordinary aggregation processes involve random merging of clusters.
  • Understanding cluster size dynamics is crucial in various scientific fields.

Purpose of the Study:

  • To generalize ordinary aggregation by introducing a choice mechanism.
  • To analyze the long-time asymptotic behavior of this new aggregation process.

Main Methods:

  • Introducing a choice in aggregation: a target cluster merges with the larger of two candidates.
  • Studying long-time asymptotic behavior and size density scaling.
  • Investigating complementary cases (merging with smaller candidate) and multi-candidate scenarios.

Main Results:

  • The size density adheres to the standard scaling form, similar to ordinary aggregation.
  • Anomalous scaling is observed in the density of the smallest clusters.
  • Both small-size and large-size tails of the density are overpopulated, reducing moderate-size clusters.

Conclusions:

  • Aggregation with choice introduces significant deviations from ordinary aggregation dynamics.
  • The introduced choice mechanism alters cluster size distribution, favoring extreme sizes.
  • Further research into variations of aggregation with choice can reveal diverse complex system behaviors.