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Updated: Mar 8, 2026

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Published on: June 21, 2021
Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome
Mehmet Tetikoğlu1, Serdar Aktas1, Haci Murat Sağdik1
1a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
Purpose:
To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.
Method:
Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.
Results:
The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014).
Conclusion:
Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.
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