New technologies for upper tract urothelial carcinoma management
Joyce Baard1, Jan Erik Freund, Jean J M C H de la Rosette
1Department of Urology, Academic Medical Center, Amsterdam, The Netherlands.
Current Opinion in Urology
|January 14, 2017
Summary
New imaging techniques and optical tools can improve the diagnosis of upper urinary tract carcinoma (UTUC). These methods enhance visualization and provide real-time optical biopsies, aiding in precise diagnosis and personalized treatment for UTUC patients.
Area of Science:
- Urology
- Medical Imaging
- Oncology
Background:
- Upper urinary tract carcinoma (UTUC) presents diagnostic challenges, particularly for flat tumors or carcinoma in situ.
- Traditional white light endoscopy has limitations in visualizing subtle malignant urothelium.
Purpose of the Study:
- To review image enhancement techniques and optical diagnostic tools for UTUC.
- To assess the evidence for their applicability and utility in diagnosing and treating UTUC.
Main Methods:
- Review of image enhancement techniques: narrow band imaging, Image1 S, photodynamic diagnosis.
- Review of optical diagnostic tools: confocal laser endomicroscopy, optical coherence tomography.
- Assessment of current evidence on applicability and utility in UTUC.
Main Results:
- Image enhancement techniques (narrow band imaging, photodynamic diagnosis) show improved tumor detection in preliminary upper tract studies.
- Optical diagnostic tools offer real-time optical biopsies for pathological information.
- Optical coherence tomography demonstrated feasibility in visualizing, grading, and staging UTUC.
Conclusions:
- Enhanced visualization and optical diagnostics can improve diagnostic precision for UTUC.
- These techniques hold promise for individualized treatment strategies in UTUC.
- Further studies are needed due to the rarity of UTUC and limited current research.
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