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Updated: Mar 8, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

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Published on: June 14, 2015

Fibrin glue for pilonidal sinus disease.

Jon Lund¹, Samson Tou², Brett Doleman³

¹Division of Health Sciences, School of Medicine, University of Nottingham, Medical School, Royal Derby Hospital, Uttoxeter Road, Derby, UK, DE22 3DT.

The Cochrane Database of Systematic Reviews

|January 14, 2017

Summary

Current evidence on fibrin glue for pilonidal sinus disease is uncertain. More high-quality studies are needed to determine its effectiveness as a standalone treatment or surgical adjunct.

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Area of Science:

Surgical Innovation
Wound Healing
Medical Adhesives

Background:

Pilonidal sinus disease commonly affects young adults, causing pain and activity impairment.
Optimal treatment for pilonidal sinus remains debated, with existing therapies having drawbacks.
Fibrin glue is being explored as a treatment option, either alone or with surgery.

Purpose of the Study:

To evaluate the efficacy of fibrin glue, used alone or with surgery, compared to surgery alone for pilonidal sinus disease.

Main Methods:

A systematic review of randomized controlled trials (RCTs) was conducted.
Searches included major databases up to December 2016, with no language or date restrictions.
Four RCTs involving 253 participants were included, all assessed as having a risk of bias.

Main Results:

Fibrin glue monotherapy showed potential for reduced pain and faster return to activities compared to Bascom's procedure, but evidence quality was low to very low.
As an adjunct to Limberg flap surgery, fibrin glue may reduce healing time and hospital stay, though evidence quality is very low.
Uncertainty exists regarding fibrin glue's effect on postoperative seroma for both Limberg and Karydakis flaps, with very low-quality evidence.

Conclusions:

The current evidence on fibrin glue for pilonidal sinus disease is limited and of very low quality due to small study sizes and risk of bias.
More robust RCTs with larger participant numbers and rigorous methodology are required to establish fibrin glue's role in treatment.
Further research should focus on clinically relevant outcomes and minimize bias to provide reliable data on fibrin glue efficacy.