Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Life Histories01:29

Life Histories

23.1K
Overview
23.1K
Autophagic Cell Death01:18

Autophagic Cell Death

4.8K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.8K
Overview of Cell Death01:30

Overview of Cell Death

10.7K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
10.7K
Necrosis01:16

Necrosis

7.0K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
7.0K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.2K
Apoptosis01:30

Apoptosis

16.4K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
16.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Treatment to Recovery: Gynecological Survivors' and Caregivers' Perspectives About the Usability of an Educational Resource.

Journal of cancer education : the official journal of the American Association for Cancer Education·2024
Same author

Canadian oncology nursing journal = Revue canadienne de nursing oncologique·2024
Same author

Developing an educational resource for gynecological cancer survivors and their caregivers: A methods and experience paper.

Canadian oncology nursing journal = Revue canadienne de nursing oncologique·2024
Same author

The needs of gynecological cancer survivors at the end of primary treatment: A scoping review and proposed model to guide clinical discussions.

Patient education and counseling·2021
Same journal

Effect of artificial intelligence on nursing documentation and patient safety.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
Same journal

Strategies for responding to anger from patients, relatives and carers.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
Same journal

Nurses' role in detecting early and subtle signs of patient deterioration in acute hospitals.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
Same journal

Pulse oximetry: exploring its role, limitations and challenges in clinical practice.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
Same journal

Anorexia nervosa: identification and management by non-specialist nurses.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
Same journal

Skin and soft tissue abscesses: assessment and management.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2026
See all related articles

Related Experiment Video

Updated: Mar 8, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.2K

Obituary.

Kathleen Robb1

  • 1Is former matron of the Royal Victoria Hospital in Belfast.

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|January 15, 2017
PubMed
Summary
This summary is machine-generated.

Doreen McCullough OBE, a prominent figure in Northern Ireland, passed away at 90. She was widely recognized as one of the region's most successful and well-known nurses.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K
Posterior Approach for Debridement of the Psoas Abscess
06:02

Posterior Approach for Debridement of the Psoas Abscess

Published on: March 2, 2020

12.1K

Related Experiment Videos

Last Updated: Mar 8, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.2K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K
Posterior Approach for Debridement of the Psoas Abscess
06:02

Posterior Approach for Debridement of the Psoas Abscess

Published on: March 2, 2020

12.1K

Area of Science:

  • Nursing
  • Healthcare Leadership
  • Northern Ireland

Background:

  • Doreen McCullough OBE was a highly respected nurse in Northern Ireland.
  • Her career spanned several decades, establishing her as a prominent figure in the field.

Purpose of the Study:

  • To commemorate the life and career of Doreen McCullough OBE.
  • To highlight her significant contributions to nursing in Northern Ireland.

Main Methods:

  • Biographical review of Doreen McCullough OBE's career.
  • Analysis of her impact on nursing standards and practices.

Main Results:

  • Doreen McCullough OBE achieved significant success and recognition in her nursing career.
  • She was known as one of Northern Ireland's most successful nurses.

Conclusions:

  • Doreen McCullough OBE left a lasting legacy in the nursing profession in Northern Ireland.
  • Her career serves as an example of dedication and success in healthcare.