And the fat lady sings about phosphate and calcium
Carsten A Wagner1, Pedro H Imenez Silva1, Isabel Rubio-Aliaga1
1Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.
Abstract:
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.
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