Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

43.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.9K
Neural Circuits01:25

Neural Circuits

3.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
3.1K
Neuroplasticity01:01

Neuroplasticity

2.2K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.2K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

4.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Dynamic regulation of neuronal vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5" [Neurobiol. Learn. Memory 225 (2026) 108161].

Neurobiology of learning and memory·2026
Same author

Direct targeting of C9ORF72 repeat RNA with fluorinated antisense oligonucleotides.

Nucleic acids research·2026
Same author

Dynamic regulation of neuronal vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5.

Neurobiology of learning and memory·2026
Same author

Epilepsy Research Institute Partner Symposium: Radically advancing research into epilepsy.

Brain and neuroscience advances·2025
Same author

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons.

Cell·2025
Same author

Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors.

The EMBO journal·2025

Related Experiment Video

Updated: Mar 8, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.7K

Tuning neural circuits by turning the interneuron knob.

Nathalie Dehorter1, Nicolás Marichal2, Oscar Marín3

  • 1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.

Current Opinion in Neurobiology
|January 15, 2017
PubMed
Summary

Interneurons are vital for brain activity; their dysfunction causes disorders. Generating new interneurons can restore circuit balance and plasticity, offering therapeutic potential.

More Related Videos

Manufacturing and Using Piggy-back Multibarrel Electrodes for In vivo Pharmacological Manipulations of Neural Responses
06:52

Manufacturing and Using Piggy-back Multibarrel Electrodes for In vivo Pharmacological Manipulations of Neural Responses

Published on: January 18, 2013

11.0K
A Guide to In vivo Single-unit Recording from Optogenetically Identified Cortical Inhibitory Interneurons
10:32

A Guide to In vivo Single-unit Recording from Optogenetically Identified Cortical Inhibitory Interneurons

Published on: November 7, 2014

19.8K

Related Experiment Videos

Last Updated: Mar 8, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

8.7K
Manufacturing and Using Piggy-back Multibarrel Electrodes for In vivo Pharmacological Manipulations of Neural Responses
06:52

Manufacturing and Using Piggy-back Multibarrel Electrodes for In vivo Pharmacological Manipulations of Neural Responses

Published on: January 18, 2013

11.0K
A Guide to In vivo Single-unit Recording from Optogenetically Identified Cortical Inhibitory Interneurons
10:32

A Guide to In vivo Single-unit Recording from Optogenetically Identified Cortical Inhibitory Interneurons

Published on: November 7, 2014

19.8K

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Neurobiology

Background:

  • Interneurons are critical for regulating neuronal circuit activity.
  • Dysfunctional interneurons are implicated in neurological and neuropsychiatric disorders.
  • Interneurons exhibit subclass-specific plasticity, crucial for temporal structuring and balancing brain activity.

Purpose of the Study:

  • To explore the role of interneuron plasticity in adult brain function.
  • To investigate the potential of interneuron transplantation for treating neurological disorders.
  • To highlight interneuron generation as a therapeutic strategy.

Main Methods:

  • Review of recent findings on interneuron plasticity mechanisms.
  • Discussion of studies involving interneuron grafting in rodent models.
  • Analysis of lineage reprogramming strategies for in vivo interneuron generation.

Main Results:

  • Interneuron subclass-specific plasticity is key to adult brain temporal structuring.
  • Grafting new interneurons can ameliorate circuit dysfunction in disease models.
  • Transplanted interneurons can reopen critical windows for circuit plasticity.

Conclusions:

  • Specific interneuron classes are crucial for circuit homeostasis and plasticity.
  • Generating new interneurons is a promising strategy for treating neurological and neuropsychiatric disorders.
  • In vivo lineage reprogramming offers a novel approach for interneuron-based therapies.