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Brain State-dependent Brain Stimulation with Real-time Electroencephalography-Triggered Transcranial Magnetic Stimulation
Published on: August 20, 2019
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Optimal trajectories of brain state transitions
Shi Gu1, Richard F Betzel2, Marcelo G Mattar3
1Applied Mathematics and Computational Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuroimage
|January 16, 2017
Summary
Brain white matter structure influences cognitive state transitions. Network control theory reveals attention and executive systems broadly control states, but mild traumatic brain injury impairs this control, increasing noise susceptibility.
Area of Science:
- Neuroscience
- Network Science
- Cognitive Science
Background:
- Neural dynamics complexity is linked to anatomical complexity.
- The role of white matter structure in constraining brain state transitions is not well understood.
Purpose of the Study:
- To model the mechanisms of brain state transitions using network control theory.
- To investigate how white matter structure constrains these transitions.
- To examine the impact of mild traumatic brain injury on brain state control.
Main Methods:
- Applied network control theory to model brain state transitions.
- Investigated control by collective region sets.
- Analyzed patient data with mild traumatic brain injury.
Main Results:
- Attention and executive control systems can influence a wide range of brain state transitions.
- These control mechanisms are not easily categorized by traditional engineering control concepts.
- Mild traumatic brain injury is associated with a loss of specificity in control processes, indicating increased vulnerability to neurophysiological noise.
Conclusions:
- White matter structure plays a crucial role in governing brain state transitions.
- The findings provide insights into healthy cognitive mechanisms and alterations post-injury.
- Network control theory offers a novel framework for understanding brain function and dysfunction.
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