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Additional considerations are required when preparing a protocol for a systematic review with multiple interventions.

Anna Chaimani1, Deborah M Caldwell2, Tianjing Li3

  • 1Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina 45110, Greece.

Journal of Clinical Epidemiology
|January 16, 2017
PubMed
Summary
This summary is machine-generated.

Standard systematic review protocols require updates for network meta-analysis. This study suggests modifications to enhance comparisons of multiple interventions in systematic reviews.

Keywords:
Comparative effectiveness reviewEligibility criteriaIndirect comparisonMixed treatment comparisonNetwork meta-analysisTransitivity

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Area of Science:

  • Medical Research Methodology
  • Evidence Synthesis

Background:

  • Network meta-analysis is increasingly used to compare multiple interventions in systematic reviews.
  • Standard systematic review protocols may not adequately address the complexities of network meta-analysis.

Purpose of the Study:

  • To highlight modifications needed for standard systematic review protocols when conducting network meta-analyses.
  • To provide guidance on adapting protocols for comparing multiple interventions.

Main Methods:

  • The Cochrane systematic review protocol format was used as a reference.
  • Considerations for pairwise reviews were compared with those for multiple intervention comparisons.
  • New protocol sections for network meta-analysis, including assumption evaluation, were proposed.

Main Results:

  • Standard protocols for pairwise meta-analysis require extensions for network meta-analysis.
  • Specific modifications and new sections are suggested for network meta-analysis protocols.

Conclusions:

  • Systematic review protocols need to be extended to handle the complexity of network meta-analysis.
  • The suggested modifications are applicable to both Cochrane and non-Cochrane systematic reviews.