Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone morphodifferentiation and tumorigenesis.

Perspectives in biology and medicine·2015
Same author

A new method of digital skeletal traction.

Medical bulletin. United States. Army. Forces in the European Theater. Office of the Theater Chief Surgeon·2010
Same author

Complete dislocations of the acromiclavicular joint; the nature of the traumatic lesion and effective methods of treatment with an analysis of forty-one cases.

The Journal of bone and joint surgery. American volume·2010
Same author

Calcification and ossification in healing fractures.

Transactions. Conference on Metabolic Aspects of Convalescence·2010
Same author

Injuries to the hip joint traumatic dislocations incurred chiefly in jeep accidents in World War II.

American journal of surgery·2010
Same author

The management of battle-incurred compound fractures in the region of the hip joint.

Military surgeon·2010
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
10:03

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

Bovine tooth-derived bone morphogenetic protein.

T Kawai1, M R Urist

  • 1UCLA Bone Research Laboratory, 90024-1790.

Journal of Dental Research
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Bovine teeth contain osteo-inductive proteins capable of bone formation. These proteins, primarily found in hard dental tissues, show activity comparable to bone morphogenetic proteins.

More Related Videos

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone
10:03

Tissue Preparation and Immunostaining of Mouse Craniofacial Tissues and Undecalcified Bone

Published on: May 10, 2019

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement
05:25

Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

Published on: July 21, 2023

Area of Science:

  • Biochemistry
  • Biomaterials Science
  • Dental Research

Background:

  • Noncollagenous proteins in dental tissues are poorly understood.
  • Osteo-inductive potential of dental hard tissues has not been extensively characterized.

Purpose of the Study:

  • To investigate the osteo-inductive potential of noncollagenous proteins extracted from bovine dental tissues.
  • To characterize the molecular weight and activity of these proteins.

Main Methods:

  • Dental tissues (dentin, enamel, cementum) were dissected, defatted, and decalcified.
  • Noncollagenous proteins were extracted and fractionated using chromatography techniques.
  • Osteo-inductive activity was assessed by implantation in mice and quantified using image analysis.

Main Results:

  • 71%–83% of dental hard tissue implants induced bone formation.
  • Osteo-inductive activity was associated with proteins of 15–28 kDa.
  • Unerupted teeth yielded greater bone formation than erupted teeth.
  • Dental soft tissues contained a 14-kDa protein with no osteo-inductive activity.

Conclusions:

  • Bovine dental hard tissues contain osteo-inductive proteins.
  • The molecular weight range of these proteins is comparable to bovine bone morphogenetic proteins.
  • Dental tissue proteins represent a potential source for bone regenerative therapies.