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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Related Experiment Video

Updated: Mar 8, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Cell-selective proteomics for biological discovery.

Shannon E Stone¹, Weslee S Glenn¹, Graham D Hamblin¹

¹Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, United States.

Current Opinion in Chemical Biology

|January 16, 2017

Summary

This summary is machine-generated.

Researchers developed new chemical tools for cell-selective proteomic analysis. This allows detailed study of specific cell groups within complex biological systems, overcoming limitations of average cell analysis.

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Published on: November 15, 2017

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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

Area of Science:

Proteomics
Cell Biology
Chemical Biology

Background:

Cells dynamically adjust their protein content (proteome) in response to environmental and developmental signals.
Analyzing the entire proteome in heterogeneous environments is challenging due to cellular diversity.
Previous methods struggled to provide insights into specific cell subpopulations within complex biological systems.

Purpose of the Study:

To highlight recent advancements in chemical tools for cell-selective proteomic analysis.
To address the limitations of global proteomic analysis in heterogeneous biological systems.
To showcase the application of these tools in diverse biological contexts.

Main Methods:

Development of novel chemical tools for targeted protein analysis.
Application of advanced sequencing, protein labeling, and mass spectrometry techniques.
Utilizing sophisticated data analysis for interpreting complex proteomic data.

Main Results:

Demonstrated the capability of new chemical tools to perform cell-selective proteomic analysis.
Successfully applied these methods to study specific cell subpopulations in complex systems.
Showcased the utility of these tools across a range of biological models, from bacteria to animals.

Conclusions:

Cell-selective proteomic analysis using advanced chemical tools offers a powerful approach to study cellular heterogeneity.
These tools overcome the limitations of traditional global proteomic analysis in complex environments.
The highlighted methods provide new avenues for investigating cellular responses in diverse biological systems.