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Updated: Mar 8, 2026

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model
Published on: February 10, 2023
Intervention for Cardiac Repair: A Clinical Perspective
Esther Hui Na Tan, Zhe Yuan Tay, Boon Seng Soh1
1Institute of Molecular and Cell Biology - Stem Cell, Regenerative Medicine And Ageing Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore.
Cardiovascular disease causes significant mortality. Novel stem cell and gene therapies show promise for cardiac tissue regeneration, aiming for clinical application.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Stem Cell Therapy
Background:
- Cardiovascular disease is the leading global cause of death.
- Cardiac injury leads to irreversible heart damage and functional decline.
- Current treatments lack the ability to regenerate cardiac tissue or fully replace heart function.
Purpose of the Study:
- To review emerging therapies for cardiac tissue regeneration.
- To assess the clinical feasibility of novel regenerative approaches.
- To guide research towards effective bedside applications for heart repair.
Main Methods:
- Review of current stem cell and genetic therapy research.
- Analysis of preclinical data in cardiac disease models.
- Evaluation of potential for clinical translation and bedside implementation.
Main Results:
- Stem cell and genetic therapies demonstrate potential in preclinical models.
- Several novel approaches are advancing towards human clinical trials.
- Significant progress is being made in developing regenerative strategies.
Conclusions:
- Regenerative medicine offers promising avenues for treating cardiovascular disease.
- Further research is needed to optimize therapies for clinical use.
- Translational research is crucial for bringing new heart repair strategies to patients.
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08:14Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
Published on: March 17, 2020
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