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Updated: Mar 8, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
Distant spread of a supratentorial glioblastoma to the spinal cord
Krishnan Ravindran1, Frank Gaillard2, Arian Lasocki3
1Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia.
Abstract:
Extracranial spread from a glioblastoma is rare. We present a case of a 48year-old man with a previously radiologically-stable left temporal lobe glioblastoma presenting with symptoms referrable to the spinal cord. MRI revealed a spinal cord lesion, with the differential including transverse myelitis and tumour. Open surgical biopsy revealed high-grade astrocytoma. Genetic analysis of both the supratentorial and spinal tumours revealed R132H IDH1 mutations, providing evidence that the spinal cord lesion had spread from the supratentorial tumour.
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