Related Experiment Video
Updated: Mar 8, 2026

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
Published on: March 31, 2022
Intracerebroventricular Delivery as a Safe, Long-Term Route of Drug Administration
Jessica L Cohen-Pfeffer1, Sridharan Gururangan2, Thomas Lester1
1BioMarin Pharmaceutical Inc, Novato, California.
Abstract:
Intrathecal delivery methods have been used for many decades to treat a broad range of central nervous system disorders. A literature review demonstrated that intracerebroventricular route is an established and well-tolerated method for prolonged central nervous system drug delivery in pediatric and adult populations. Intracerebroventricular devices were present in patients from one to 7156 days. The number of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient (range, 1.0% to 33.0%) were similar to infectious complication rates (0.0% to 27.0%). Clinician experience and training and the use of strict aseptic techniques have been shown to reduce the frequency of complications.
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