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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Adenosine and preeclampsia.

Rocío Salsoso1, Marcelo Farías2, Jaime Gutiérrez3

  • 1Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, Seville E-41012, Spain.

Molecular Aspects of Medicine
|January 17, 2017
PubMed
Summary

Adenosine signaling, including its transporters and receptors, plays a crucial role in preeclampsia pathophysiology. Altered adenosine pathways contribute to pregnancy complications, impacting maternal and fetal health.

Keywords:
AdenosineAdenosine receptorEndotheliumPlacentaPreeclampsiaTrophoblast

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Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Physiology
  • Cellular and Molecular Medicine

Background:

  • Preeclampsia is a serious pregnancy complication affecting 3-5% of pregnancies.
  • Adenosine, an endogenous nucleoside, influences circulation, immune function, and glucose homeostasis.
  • Changes in adenosine pathways are linked to pregnancy pathologies like preeclampsia.

Purpose of the Study:

  • To review the evidence on adenosine's involvement in preeclampsia.
  • To explore the role of adenosine transporters, receptors, and signaling in preeclampsia pathophysiology.
  • To discuss potential therapeutic implications of targeting adenosine pathways.

Main Methods:

  • Literature review of studies on adenosine and preeclampsia.
  • Analysis of evidence linking adenosine signaling to placental function and maternal health.
  • Synthesis of current understanding of adenosine's role in preeclampsia.

Main Results:

  • Preeclampsia is associated with increased maternal blood and placental adenosine concentrations.
  • Abnormal expression/function of nucleoside transporters and adenosine receptors are observed in preeclampsia.
  • Adenosine receptor activation may influence trophoblast invasion, angiogenesis, and ischemia/reperfusion.

Conclusions:

  • Adenosine pathways are implicated in preeclampsia development and progression.
  • Altered adenosine signaling may contribute to placental dysfunction and adverse pregnancy outcomes.
  • Further research into adenosine's role could reveal novel therapeutic strategies for preeclampsia.