Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.8K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

706
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
706
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

848
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
848
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

400
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
400
Fractures: Bone Repair01:27

Fractures: Bone Repair

6.1K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
6.1K
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

438
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
438

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward Bridging the Gap from Artificial Intelligence in Clinical Research to Clinical Practice in Rheumatology: The Mayo Experience.

Rheumatic diseases clinics of North America·2026
Same author

Efficacy and safety of belimumab and anifrolumab in systemic lupus erythematosus: A systematic review and network meta-analysis.

Seminars in arthritis and rheumatism·2026
Same author

The Association of Osteoarthritis With De Novo Inflammatory Arthritis in Patients Receiving Immune Checkpoint Inhibitors: A Retrospective Study.

Arthritis care & research·2026
Same author

The evolving comorbidity landscape of rheumatoid arthritis.

Nature reviews. Rheumatology·2026
Same author

Deep Learning-Based Comparison of Knee Minimum Joint Space Width in Patients With Rheumatoid Arthritis and Osteoarthritis Before Total Knee Arthroplasty.

The Journal of rheumatology·2026
Same author

Association of Diet, Supplements, and Physical Activity With Risk of Incident Spondyloarthritis.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Related Experiment Video

Updated: Mar 8, 2026

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.3K

Fragility Fractures Are Associated with an Increased Risk for Cardiovascular Events in Women and Men with Rheumatoid

Orla Ni Mhuircheartaigh1,2, Cynthia S Crowson1,2, Sherine E Gabriel1,2

  • 1From the St. Vincent's Hospital, Dublin, Ireland; Division of Biomedical Statistics and Informatics, and Division of Epidemiology, Department of Health Sciences Research, and Division of Rheumatology, and Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota; Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

The Journal of Rheumatology
|January 17, 2017
PubMed
Summary

A fragility fracture in patients with rheumatoid arthritis (RA) significantly predicts cardiovascular disease (CVD) risk in both men and women. This finding highlights the need for increased CVD screening and prevention in RA patients who experience fractures.

Keywords:
CARDIOVASCULAR DISEASEFRACTUREHEART FAILUREISCHEMIC HEART DISEASERHEUMATOID ARTHRITIS

More Related Videos

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K

Related Experiment Videos

Last Updated: Mar 8, 2026

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
06:31

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

3.3K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.4K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Rheumatoid arthritis (RA) patients face elevated risks for both fragility fractures and cardiovascular disease (CVD).
  • These conditions contribute to increased morbidity and mortality in RA patients.
  • Fragility fractures may occur at younger ages in RA patients compared to the general population, sharing risk factors with CVD.

Purpose of the Study:

  • To determine if a fragility fracture predicts the development of CVD in individuals with RA.
  • To investigate this association in both women and men diagnosed with RA.

Main Methods:

  • A population-based cohort study compared RA patients (1955-2007) with age- and sex-matched non-RA controls.
  • Fragility fractures and CVD events were identified post-RA incidence, with risk factors modeled as time-dependent covariates.
  • Cox models were used to analyze the association between fractures and subsequent CVD development.

Main Results:

  • The study included 1171 subjects in both RA and non-RA cohorts.
  • RA patients experienced 406 fragility fractures and 286 CVD events, while non-RA controls had 346 fractures and 225 CVD events.
  • RA subjects with fragility fractures showed a significantly increased CVD risk (HR 1.81), unlike non-RA subjects (HR 1.18).

Conclusions:

  • Fragility fractures in RA patients are linked to a higher risk of CVD events.
  • Clinicians should use fragility fractures as an alert for intensified CVD screening and preventive strategies in RA patients.
  • These findings apply to both women and men with rheumatoid arthritis.