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Kidney disease and obesity: epidemiology, mechanisms and treatment

Niels Olsen Saraiva Câmara1, Kunitoshi Iseki2, Holly Kramer3

  • 1Laboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Avenue Professor Lineu Prestes 1730, ICB IV, 05508-000, São Paulo, Brazil.

Nature Reviews. Nephrology
|January 17, 2017
PubMed

Insights

Obesity significantly impacts kidney health, increasing the risk of kidney disease. A healthy lifestyle is crucial for preventing and managing obesity-related kidney problems, promoting overall kidney wellness.

Area of Science:

  • Nephrology
  • Public Health
  • Metabolic Diseases

Background:

  • World Kidney Day 2017 focused on kidney disease and obesity.
  • Obesity is a growing global health concern with significant implications for kidney function.
  • Understanding the link between obesity and kidney disease is critical for public health initiatives.

Purpose of the Study:

  • To review the epidemiology of obesity-related kidney disease.
  • To explore the underlying mechanisms linking obesity and kidney dysfunction.
  • To discuss current and future management strategies for patients with obesity-related kidney disease.

Main Methods:

  • Expert review of current literature.
  • Synthesis of findings from leading researchers in nephrology.
  • Analysis of epidemiological data and mechanistic studies.

Main Results:

  • Obesity is a major driver of chronic kidney disease (CKD) progression.
  • Specific mechanisms include inflammation, oxidative stress, and hormonal imbalances.
  • Current management focuses on lifestyle changes, weight loss, and pharmacological interventions.

Conclusions:

  • A healthy lifestyle is paramount for preventing and managing obesity-related kidney disease.
  • Novel therapeutic targets are emerging from research into underlying mechanisms.
  • Further basic and clinical research is essential to improve patient outcomes.

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