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Related Experiment Video

Updated: Mar 8, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Update on Chronic Lung Allograft Dysfunction.

Jason M Gauthier¹, Ramsey R Hachem², Daniel Kreisel³

¹Department of Surgery, Washington University in St. Louis, Saint Louis, MO.

Current Transplantation Reports

|January 17, 2017

Summary

This summary is machine-generated.

Chronic lung allograft dysfunction (CLAD) is lung transplant rejection causing airflow obstruction. Tailoring treatments to unique CLAD phenotypes is crucial, as prevention is key due to poor treatment response.

Keywords:

azithromycin responsive allograft dysfunction bronchiolitis obliterans bronchiolitis obliterans syndrome chronic lung allograft dysfunction neutrophilic reversible allograft dysfunction restrictive allograft syndrome

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Area of Science:

Medicine
Immunology
Transplantation

Background:

Chronic lung allograft dysfunction (CLAD) impairs transplanted lung function, often due to chronic rejection.
CLAD presents with airflow restriction/obstruction, significantly impacting long-term transplant success.
Three distinct CLAD phenotypes (bronchiolitis obliterans, neutrophilic reversible allograft dysfunction, restrictive allograft syndrome) are now recognized.

Purpose of the Study:

To highlight the distinct pathologies of recognized CLAD phenotypes.
To emphasize the need for tailored treatment strategies based on specific CLAD etiology.
To underscore the critical importance of preventing CLAD due to limited treatment efficacy.

Main Methods:

Review of recent investigations into CLAD phenotypes.
Analysis of histopathological findings associated with different CLAD types.
Examination of contributions from small and large animal models in CLAD research.

Main Results:

Each CLAD phenotype exhibits unique pathology and histopathological characteristics.
Understanding these differences suggests the necessity for individualized treatment approaches.
CLAD is challenging to treat effectively once established, reinforcing prevention importance.

Conclusions:

Tailoring treatments to specific CLAD phenotypes is essential for improving outcomes.
Preventing CLAD development is paramount due to its poor response to interventions.
Further research, including animal models, is needed to develop effective human treatments.