Related Experiment Video
Updated: Mar 8, 2026
06:33
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
2.0K
Mesenchymal stromal cells in myeloid malignancies
Thomas Schroeder1, Stefanie Geyh1, Ulrich Germing1
1Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Medical Faculty, Düesseldorf, Germany.
Blood Research
|January 17, 2017
Summary
The bone marrow microenvironment, especially mesenchymal stromal cells (MSC), significantly contributes to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) development. Therapeutic strategies targeting MSC interactions may offer new treatments for these myeloid malignancies.
Area of Science:
- Hematology
- Oncology
- Stem Cell Biology
Background:
- Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal myeloid disorders originating from hematopoietic stem and progenitor cells (HSPC).
- Research traditionally focused on HSPC defects, but the bone marrow (BM) microenvironment's role in myeloid malignancies is gaining attention.
- The BM microenvironment's physiological role in regulating hematopoiesis and its potential to induce MDS/AML when genetically disrupted has been demonstrated.
Conclusions:
- The BM microenvironment is integral to the pathogenesis of MDS and AML, not just the malignant cells themselves.
- Therapeutic interventions targeting the BM microenvironment and its interactions with malignant cells represent a promising avenue for treating myeloid malignancies.
- Further research into these interactions will refine models of disease and guide the development of effective treatments.
Related Concept Videos
01:19Mesenchymal Stem Cells
5.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.7K
01:21Stem Cell Therapy for Tissue Regeneration
4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K
01:15Differentiation of Common Myeloid Progenitor Cells
4.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.1K
01:01Regulation of Hematopoietic Stem Cells
4.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.2K
01:19Multipotency of Hematopoietic Stem Cells
4.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.0K
02:40Cancer Stem Cells and Tumor Maintenance
6.2K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.2K