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Related Concept Videos

Proteomics01:33

Proteomics

10.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

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Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
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Related Experiment Video

Updated: Mar 8, 2026

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
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Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

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Complementing genomics and transcriptomics: Phosphoproteomics illuminates systems biology in prostate cancer.

Victor M Tan1, Larry C Cheng1, Justin M Drake2

  • 1Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA; Graduate Program in Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ, USA; Graduate Program in Quantitative Biomedicine, Graduate School - New Brunswick, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

Molecular & Cellular Oncology
|January 17, 2017
PubMed
Summary

This study integrates phosphoproteomics with genomics to reveal key signaling pathways in advanced prostate cancer. Computational methods identify crucial kinase networks for potential therapeutic targets.

Keywords:
Castration-resistant prostate cancerkinasesphosphoproteomicsprecision medicinesystems biology

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Area of Science:

  • Biochemistry
  • Oncology
  • Bioinformatics

Background:

  • Advanced prostate cancer involves complex signaling networks.
  • Genomics and transcriptomics offer partial insights into these networks.

Purpose of the Study:

  • To integrate phosphoproteomics with genomics and transcriptomics.
  • To identify critical kinase signaling networks in advanced prostate cancer.

Main Methods:

  • Utilized computational approaches for data integration.
  • Focused on phosphoproteomic data analysis.

Main Results:

  • Identified key kinase signaling networks in advanced prostate cancer.
  • Established a comprehensive overview of cellular signaling.

Conclusions:

  • Integrated phosphoproteomics enhances understanding of advanced prostate cancer signaling.
  • Findings support immediate preclinical and future clinical applications.