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Synchronous Presentation of Renal Cell Carcinoma and Hodgkin Lymphoma in an Adolescent
Mohamed Y Elsaid1, Kara G Gill, Ankush Gosain
1*Department of Pediatrics, Froedtert Health & Medical College of Wisconsin, Milwaukee Departments of ¶Pediatrics, Pediatric Hematology Oncology & Bone Marrow Transplant †Radiology §Surgery ∥Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI ‡Department of Surgery, University of Tennessee Health Science Center, Memphis, TN.
Background:
Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children.
Observation:
We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy.
Conclusions:
This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.
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