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Association between thyroid autoimmunity and Helicobacter pylori infection
Yun Mi Choi1, Tae Yong Kim1, Eui Young Kim2
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The Korean Journal of Internal Medicine
|January 17, 2017
Summary
Helicobacter pylori infection is linked to a higher prevalence of anti-thyroid peroxidase antibodies, suggesting a potential role in autoimmune thyroiditis development. This study investigated the association in Korean adults.
Area of Science:
- Endocrinology
- Gastroenterology
- Immunology
Background:
- Controversial reports link Helicobacter pylori infection to autoimmune thyroid disease (AITD).
- Data on this association is limited in Asian populations with high H. pylori prevalence.
Purpose of the Study:
- To investigate the association between H. pylori infection and AITD in Korean adults.
- To assess the prevalence of anti-thyroid peroxidase antibodies (TPO-Ab) in relation to H. pylori infection.
Main Methods:
- Analysis of 5,502 adults aged 30-70 years from a health promotion center.
- Assessment of thyroid status (free thyroxine, TSH, TPO-Ab) and H. pylori IgG antibodies.
- Comparison of TPO-Ab prevalence between H. pylori-infected and non-infected subjects.
Main Results:
- H. pylori infection was present in 52.3% of subjects; TPO-Ab positivity was 7.8%.
- TPO-Ab positivity was significantly higher in subjects with H. pylori infection (8.6% vs. 7.00%, p=0.03).
- The association remained significant after adjusting for age, sex, and BMI (OR 1.02, p=0.04).
Conclusions:
- TPO-Ab positivity is more frequent in individuals with H. pylori infection.
- H. pylori infection may contribute to the development of autoimmune thyroiditis.
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