Related Experiment Video
Updated: Mar 8, 2026
Procurement for a Vascularized and Reinnervated Abdominal Wall Allotransplantation
Published on: July 18, 2025
The biological prosthesis is a viable option for abdominal wall reconstruction in pediatric high risk defects
Osnat Zmora1, Shannon L Castle1, Stephanie Papillon1
1Department of Pediatric Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Background:
Our aim was to explore the indications for and outcome of biological prostheses to repair high risk abdominal wall defects in children.
Methods:
A retrospective chart review was performed of all cases of abdominal wall reconstruction in a single institution between 2007 and 2015. Demographic and clinical variables, technique and complications were described and compared between prosthesis types.
Results:
A total of 23 patients underwent abdominal wall reconstruction using a biological prosthesis including 17 neonates. The main indication was gastroschisis (17 patients) followed by ruptured omphalocele and miscellaneous conditions. Alloderm™ was most commonly used followed by Surgisis™, Strattice™, Flex-HD™ and Permacol™. In 22 cases wounds were contaminated or infected. Open bowel/stomas were present in 9 cases. Skin was not closed in 11 cases. Post-operative complication rate was 30% and hernia recurrence rate was 17% after a mean follow-up time of 16 months.
Conclusions:
The use of a biological prosthesis may offer advantages over a synthetic mesh in pediatric high risk abdominal wall defects. The surgeon should be ready to consider its use in selected cases.
More Related Videos
20:33A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
Published on: July 4, 2019
05:47Use of a Rat Model to Study Ventral Abdominal Hernia Repair
Published on: October 2, 2017