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Moyamoya and Inflammation.

Juan C Mejia-Munne1, Jason A Ellis2, Neil A Feldstein2

  • 1Department of Neurosurgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.

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|January 18, 2017
PubMed
Summary
This summary is machine-generated.

Moyamoya disease is linked to inflammatory conditions in children and adults. This study analyzed patient data, finding associations with atherosclerotic and juvenile autoimmune diseases, suggesting further research into these connections.

Keywords:
Autoimmune diseaseHemorrhageNational Inpatient SampleStrokeVasculitis

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Area of Science:

  • Neurology
  • Immunology
  • Epidemiology

Background:

  • Moyamoya disease etiology remains unknown despite over 50 years since its initial description.
  • While genetic and immunologic factors are implicated, they don’t fully explain moyamoya disease pathophysiology.
  • A potential link between moyamoya disease and inflammatory conditions has been suggested but not extensively studied.

Purpose of the Study:

  • To investigate the epidemiologic association between moyamoya disease and various inflammatory diseases.
  • To analyze data from a large administrative database to explore these associations across different age groups.

Main Methods:

  • Utilized the National Inpatient Sample database from 2009-2012.
  • Identified moyamoya disease and inflammatory diseases using International Classification of Disease, 9th revision codes.
  • Grouped patients into inflammatory disease clusters: atherosclerotic, adult-onset autoimmune, and juvenile-onset autoimmune diseases.

Main Results:

  • A total of 2633 moyamoya disease admissions were analyzed.
  • Moyamoya disease showed significant associations with atherosclerotic and juvenile-onset autoimmune diseases in both pediatric and adult patients.
  • Adult-onset autoimmune disease was associated with moyamoya disease in pediatric patients but not in adults.

Conclusions:

  • Moyamoya disease demonstrates associations with specific inflammatory disease clusters in both pediatric and adult populations.
  • These findings highlight a potential pathophysiologic link between moyamoya disease and inflammatory processes.
  • Further research is recommended to elucidate the mechanisms underlying the association between moyamoya disease and inflammatory conditions.