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[Female obesity in life cycle]
1Department of Obstetrics and Gynecology, Miyazaki Medical College.
Nihon Sanka Fujinka Gakkai Zasshi
|August 1, 1989
Summary
Aging impacts body fat, influencing obesity and reproductive health. Adequate body fat is crucial for menarche, while obesity can disrupt menstrual cycles and pregnancy due to hormonal imbalances.
Area of Science:
- Endocrinology
- Reproductive Biology
- Gerontology
Context:
- Adipose tissue quantity and distribution change with age, affecting overall body fat.
- Obesity is influenced by aging, with Kaup's index correlating with fat tissue thickness and waist-hip ratio increasing in older adults.
Purpose:
- To evaluate the role of body fat in reproductive function, particularly concerning menarche and menstrual disorders in obese women.
- To explore the central and peripheral mechanisms underlying menstrual irregularities in obese women and the impact of hyperandrogenism.
Summary:
- A body fat ratio of 22-24% is necessary for menarche, with lower ratios in non-menarcheal girls.
- Hypothalamic dysfunction can lead to overfeeding and gonadal dysfunction, causing obesity and menstrual disorders.
- Peripheral mechanisms include fat-soluble hormone accumulation and extraglandular estrogen production, contributing to hyperestrogenism and hyperandrogenism in obese women.
Impact:
- Understanding the relationship between body fat, aging, and reproductive health is vital for clinical interventions.
- Weight reduction in obese women with hyperandrogenism can help regularize menstrual cycles and potentially improve fertility outcomes.