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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
Published on: May 12, 2023
Rabies virus vaccine as an immune adjuvant against cancers and glioblastoma: new studies may resurrect a neglected
M A Altinoz1, S Guloksuz2,3, I Elmaci4
1Neuro-Academy Research Group, Sisli, Istanbul, Turkey. maltinoz@gmail.com.
Abstract:
To review the literature about the use of Rabies Virus-Vaccine (RV-V) as an anticancer immunotherapeutic modality in the light of recent findings. The literature search in relevant databases with the following key words: Rabies virus, cancer, remission. Remissions occured following RV-V injections in patients with cervical cancer and melanoma. Pilot clinical studies showed that RV-V injections enhanced survival in glioblastoma patients, which is supported by findings in GL261 mouse glioma model. If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic.
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