Cobalt(II)-Catalyzed Oxidative C-H Arylation of Indoles and Boronic Acids
Xinju Zhu1, Jian-Hang Su1, Cong Du1
1College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou 450001, P. R. China.
Abstract:
Co(II)-catalyzed C-H C2 selective arylation of indoles with boronic acids through monodentate chelation assistance has been achieved for the first time. The unique features of this methodology include mild reaction conditions, highly C2 regioselectivity, and employment of a Grignard reagent-free catalytic system. A wide range of substrates, including unreactive arenes, are well tolerated, which enables the construction of the coupling products efficiently. This new strategy provides an alternative and versatile approach to construct biaryls using inexpensive cobalt catalyst.
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