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Updated: Mar 8, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Antifungal activity of substituted aurones
Caleb L Sutton1, Zachary E Taylor2, Mary B Farone1
1Department of Biology, Middle Tennessee State University, Murfreesboro, TN 37132, United States; Tennessee Center for Botanical Medicinal Research, Middle Tennessee State University, Murfreesboro, TN 37132, United States.
Abstract:
Novel antifungals are in high demand as there is a growing resistance to antifungals currently in use. In particular, opportunistic fungal infections caused by Candida spp. are on the rise with infections by this genus accounting for the most severe fungal infections following chemotherapy, implantation procedures, and in patients with HIV/AIDS. A series of simple aurone analogs were synthesized and screened for antifungal activity versus Candida spp. Several compounds displayed activity at 100μM, with two having IC50 values below 20μM for three species of Candida. One of the compounds tested here also exhibits anti-biofilm activity for mid-maturation growth.
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