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Relationship between age and cardiometabolic index in Japanese men and women
1Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Insights
Age impacts the cardiometabolic index (CMI) differently in men and women. The link between CMI and diabetes risk diminishes with advancing age in both sexes.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Cardiometabolic index (CMI) is recognized for its role in discriminating diabetes risk and its association with atherosclerosis.
- The influence of age on CMI and its relationship with diabetes risk remains largely unexplored.
Purpose of the Study:
- To investigate how age influences the cardiometabolic index (CMI) in Japanese men and women.
- To examine the association between CMI and diabetes across different age groups.
Main Methods:
- A cross-sectional study involving 35,684 Japanese men and 18,793 women aged 35-70 years.
- Comparison of CMI and its correlation with diabetes across various age strata.
- Multivariate analyses were performed adjusting for lifestyle factors.
Main Results:
- CMI was significantly higher in men than women.
- In men, CMI peaked in middle age, while in women, it increased with age.
- The odds of diabetes associated with CMI decreased with advancing age in both genders.
Conclusions:
- Age exerts differential effects on CMI in men and women.
- The predictive value of CMI for diabetes risk diminishes with increasing age in both sexes.
Background:
Cardiometabolic index (CMI) is a new discriminator of the risk of diabetes and has been reported to be associated with the degree of atherosclerosis. However, it is unknown whether and how age influences CMI.
Methods:
The subjects were Japanese men (n=35684) and women (n=18793) aged ≥35 and ≤70 years who had received periodic health examinations at workplaces. CMI and its association with diabetes were compared among different age groups in men and women.
Results:
CMI was much higher in men than in women (median: 1.06 vs. 0.59). In men, CMI was significantly higher in the middle-aged (40-49 and 50-59 years) groups than in the youngest (35-39 years) and oldest (60-70 years) groups and was significantly higher in the oldest group than in the youngest group. In women, CMI tended to be higher with an increase of age, and log-transformed CMI was significantly correlated with age (Pearson's correlation coefficient: 0.235, p<0.01). Both in men and women, odds ratios of CMI (high vs. not high) for diabetes were significantly higher than the reference level in all of the age groups and tended to be lower with an increase of age. The above relationships among age, CMI and diabetes were also found in multivariate analyses adjusting for histories of smoking, alcohol drinking and regular exercise.
Conclusions:
Age influences CMI differently in men and women, and the association between CMI and diabetes became weaker with an increase of age both in men and women.
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